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Mesterolone (Proviron)

History:   Currently produced by the pharmaceutical company Schering, Mesterolone was heavily researched in the 1970’s.  For a brief period of time, it was evaluated for effectiveness as an anti-depressant, but with subsequent research showing Mesterolone to be less effective than newer treatment options, it is no longer considered an appropriate medication for this purpose.  Although rare, Mesterolone is sometimes prescribed as a treatment for men suffering from low libido.

Method of Administration:  Mesterolone is administered in oral form.

Steroid Class:  Mesterolone is a DHT derivative, belonging to the DHT-family of steroids.

Primary Use:  Unlike nearly every other steroid, Proviron is not used for muscle-building.  In fact, the drug displays almost no anabolic activity at all.  Despite this shortcoming, Mesterolone has retained its popularity due to the unique qualities it possesses.  There are 3 primary uses for which this drug is best suited, which are:  1) Its ability to reduce circulating estrogen  2) Its exceptional SHBG binding affinity  3) Its ability to increase libido.   Mesterolone reduces circulating estrogen by exhibiting a stronger binding affinity for the aromatase enzyme comparative to testosterone.  This directly decreases the amount of aromatase enzyme testosterone has to interact with, thereby decreasing testosterone’s estrogen conversion rate.   This reduced estrogen level can have several different effects on the user, such as the prevention of estrogen mediated side effects, to cosmetic enhancements like reduced water retention and increased muscle hardness.  Proviron is also frequently used to help maximize the muscle-building potential of one’s cycle by indirectly increasing the level of free testosterone/AAS available to muscle tissue, which it accomplishes by reducing levels of sex hormone binding globulin.  Last but not least, Proviron is regularly used for libido enhancement, with many considering it to be the single most effective treatment option for this purpose. 

Anabolic-Androgenic Ratio:  30:100

Aromatizable:  No.  Exhibits anti-estrogenic activity. 

Progestagenic Activity:  No. 

Methylated:  Yes.  Methylation serves as a protective feature of most oral AAS, allowing the molecule the pass through the liver and enter the bloodstream intact, after which it can travel to muscle tissue and exert its muscle-building effects.

Standard Dosing Range and Cycle Length:  Mesterolone is commonly dosed at 25-100 mg per day for a period of 6-16 weeks.

Frequency of Administration:  Daily use; Split into 2 equally divided doses.