History: Considered revolutionary at the time of its introduction, Anastrozole was brought to the market by Astra Zeneca for the treatment of breast cancer. It was the 1st next-generation A.I. and since its release, multiple similar AI’s have been produced, but Arimidex continues to remain one of the most effective.
Method of Administration: Anastrozole is administered in oral form.
Drug Class: Aromatase Inhibitor.
Primary Use: Anastrozole, like all anti-estrogens, is used to help normalize/maintain estrogen levels within the body. Aside from the prevention of estrogenic side effects, estrogen management can assist users in maintaining a hard & dry appearance when using aromatizable drugs. This is especially useful prior to a contest, when displaying this looks is essential to success. Anastrozole accomplishes this function by binding with the aromatase enzyme, which is responsible for converting testosterone (and other aromatizable drugs) into estrogens. Unlike a suicide aromatase inhibitor, Anastrozole does not permanently bind with the aromatase enzyme, but will detach after a certain period of time. This opens up the individual to the possibility of estrogen rebound, which is when the user experiences a brief period of elevated estrogen levels after cessation of the drug. In most cases, this rebound is not significant enough to cause any issues, but for those who do find this to be problematic, it is easily dealt with by gradually reducing the dosage of Anastrozole over a couple of weeks before finally discontinuing the drug. One advantage of Anastrozole is its relatively infrequent dosing schedule.
Anabolic-Androgenic Ratio: N/A.
Aromatizable: No. Exhibits anti-estrogenic activity.
Progestagenic Activity: No.
Standard Dosing Range and Cycle Length: Anastrozole is commonly administered at a dosage of .5 mg every other day to 1 mg per day. Dosing requirements will be determined by the number, type, and amount of aromatizable drugs being used.
Frequency of Administration: Due to Anastrozole’s long active life, it can be dosed as infrequently as every other day, although more even blood concentrations are achieved with daily dosing. The drug is typically administered as long as aromatizable drugs are present